Digital technologies help clinical development organizations address challenges with recruitment costs, patient enrollment, study design, protocol compliance, safety reporting, and participant trial completion. To successfully deliver superior experiences to clinical trial participants, firms must capitalize on opportunities to build and upgrade their digital capabilities. Clinical trial teams should turn their attention to the two broad categories of on-stage and back-end digital capabilities. On-stage capabilities such as virtual communication channels, eConsent, and adherence tools help clinical trial teams create in-trial touchpoints to help patients successfully complete their trial journey. Behind-the-scenes capabilities such as CRM systems, real-world databases, analytical models, and compliance tools are invisible to participants but essential to digital trial platform success.